TY - JOUR T1 - Parental history of atopy modifies the effect of breast feeding on recurrent wheeze in infants JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1634 AU - Patricia Garcia-Marcos AU - Rosa Pacheco-Gonzalez AU - Manuel Sanchez-Solis AU - Javier Mallol AU - Paul Brand AU - Dirceu Sole AU - Luis Garcia-Marcos Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1634.abstract N2 - Aim: To know how family history of atopy modifies the protective effect of breast feeding (3+ months) (BF) on recurrent wheeze (3+ episodes) (RW) of infants during the 1st year of life.Methods: EISL has been described previously (Thorax 2010;65:1004-9). Briefly, parents from 22 centres answered a validated questionnaire (Int Arch Allergy Immunol 2007;144:44-50) on wheezing and risk factors during the 1st year of life of their children. Using the random effect logit model, using centre as panel variable, four models were built according to the existence of 0, 1, 2 or 3 parental (father and/or mother) atopic diseases (asthma, rhinoconjunctivitis or eczema). RW was compared to no wheeze (OR; 95% CI), and all models included as covariates: gender, smoking in pregnancy, having a cold in the 1st three months of life, attending to a nursery school, infant eczema, n. of siblings and persons at home, mould stains in the household walls and mother’s study level.Results: Of 35,049 infants, 19,811 had no wheeze and 6,161 had RW (8,962 had 1/2 episodes and 115 had no information available). Compared with male gender, which was a significant risk factor across all strata, BF tended to be increasingly more protective as family history was less atopic.View this table:Associations (odds ratios) of breast feeding and gender with recurrent wheeze according to the number of parental allergic diseasesConclusion: The protective effect of BF on RW during the 1st year of life varies according to the parental history of atopy. ER -