TY - JOUR T1 - Predictors of functional exercise capacity allogeneic hematopoietic stem cell transplantation recipients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1337 AU - Gulsah Bargi AU - Meral Bosnak Guclu AU - Zeynep Aribas AU - Burcu Camcioglu AU - Muserrefe Nur Karadalli AU - Zeynep Sahika Aki AU - Nurdan Köktürk AU - Müge Aydogdu AU - Gülsan Türkoz Sucak Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1337.abstract N2 - Background: Significant declines in functional exercise capacity occur in allogeneic hematopoietic stem cell transplant (HSCT) recipients.Aim: To investigate the relationship between functional exercise capacity and pulmonary functions, carbon monoxide diffusing capacity (DLCO), serum albumin level, respiratory and peripheral muscle strength, and to find out the best predictor of functional exercise capacity in allogeneic HSCT recipients.Methods: Thirty-six allogeneic HSCT recipients (>100 days post transplantation, 39.36±12.85 years, 12F, 24M) were included. Albumin levels were recorded, DLCO and pulmonary functions were measured. Functional exercise capacity was evaluated using 6-minute walk test (6MWT), and respiratory muscle strength (MIP, MEP) using mouth pressure device, quadriceps femoris and hand grip muscle strength using a dynamometer.Results: There was statistically significant correlation between 6MWT distance and pulmonary functions, DLCO, albumin levels, MEP, hand grip muscle strength (p<0.05). Multiple regression analysis, conducted in 36 patients demonstrated that 70% of the variance in the 6MWT distance was explained by hand grip muscle strength (R²=0.45, p<0.001), and the albumin levels (R²=0.25, p=0.002).Conclusions: Upper extremity muscle strength and albumin levels are factors significantly contributing to impaired functional capacity in allogeneic HSCT recipients. Functional exercise capacity worsens with decreasing diffusion capacity, pulmonary functions, respiratory and peripheral muscle strength. The effects of strengthening exercises and essential amino acid supplementation on functional exercise capacity should be investigated. ER -