TY - JOUR T1 - Association of polymorphisms in renin-angiotensin-aldosterone system pathway, nitric oxide synthase 3 with acute mountain sickness JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1405 AU - Akpay Sarybaev AU - Abdirashit Maripov AU - Abdybek Cholzhiev AU - Gulnur Karagulova Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1405.abstract N2 - There are a number of researches which examined the genetic component in the susceptibility to high altitude pulmonary edema, unlike of acute mountain sickness (AMS) at high altitude (HA). The most studied genes are renin, angiotensin, angiotensin converting enzyme, angiotensin II receptor (type I and II), aldosterone synthase and NOS3 in high altitude maladies. Methods. Fourty six Kyrgyz males were brought to HA (3200 m) from 750 m above sea level. Six of them suffered from acute mountain sickness. Lake Louise self-questionnaire was used for the diagnosis of AMS (3 or more points). Six genetic variants such as α-adductin (ADD1), angiotensinogen (AGT), aldosterone synthase (CYP11B2), angiotensin II receptor type 1 (AGTR1) and nitric oxide synthase 3 have been investigated. Results. Our study demonstrated a strong association between the polymorphism existing in the RAAS pathway CYP11B2 C-344T and susceptibility to AMS (χ-square was 8,21, p <0,005). No significant differences were observed between the rest gene polymorphisms and AMS susceptibility. Conclusion: CYP11B2 C-344T may be associated with the increased risk of AMS development. However the further researches are needed to confirm our preliminary results. ER -