TY - JOUR T1 - The impact of bronchiectasis on outcomes in a large cohort of patients hospitalised with exacerbations of COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 4647 AU - Richard Stretton AU - Stuart Schembri AU - Philip Short AU - Lucy Poppelwell AU - Aran Singnayagam AU - Ashan Akram AU - Thomas Fardon AU - James Chalmers AU - Peter Williamson Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/4647.abstract N2 - Introduction: Bronchiectasis is common in severe COPD, but its impact on outcomes after exacerbations of COPD has not been reported.Methods: Analysis was performed on a prospective multicentre observational database of patients hospitalised in the UK with exacerbations of COPD (2009-2011). Patients with co-existing bronchiectasis were compared to those with COPD. Outcomes were assessed adjusting for confounders using cox-proportional hazard regression.Results: Of 1343 patients, 136 had a co-existing diagnosis of bronchiectasis. Baseline demographics between the groups were similar (Table 1).View this table:Table 1Patients with bronchiectasis had significantly increased 30-day mortality hazard ratio (HR) 2.2 95% CI 1.1-4.3,p=0.03, despite a higher proportion with acidosis in the non-bronchiectasis group. Patients with bronchiectasis had a higher positive yield for microbiology and an appropriately prolonged antibiotic course.After discharge, patients with bronchiectasis had an increased risk of readmission HR 1.5 (1.03-2.2,p=0.03) and particularly respiratory readmissions HR 1.9 (1.1-3.2,p=0.01). 1 year mortality was not significantly increased HR 1.4 (0.98-1.9,p=0.06).Conclusion: Bronchiectasis is associated with higher in-hospital mortality and a higher risk of readmissions after discharge in patients with exacerbation of COPD. ER -