PT - JOURNAL ARTICLE AU - Olaia Sardon AU - Paula Corcuera AU - Ane Aldasoro AU - Javier Korta AU - Javier Mintegui AU - Jose Ignacio Emparanza AU - Eduardo G. Pérez-Yarza TI - Inflammatory patterns in asthmatic children based on the measurement of alveolar nitric oxide DP - 2013 Sep 01 TA - European Respiratory Journal PG - P1118 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P1118.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P1118.full SO - Eur Respir J2013 Sep 01; 42 AB - Background: Nitric oxide (NO) can be measured in proximal [maximum airway NO flux (J'awNO)] and distal [alveolar NO concentration (CANO)] airway.Objective: To measure J'awNO and CANO due to define four inflammatory categories in asthmatic children.Methods: A cross-sectional study was performed in healthy and asthmatic children. Exhaled NO at multiple flow rates (50, 100 y 200ml/s) was carried out by CLD88sp® analyzer. According to the two-compartment model, CANO and J'awNO were calculated. A forced spirometry was performed in asthmatic subjects who were classified as follows; type I (normal J'awNO and CANO), type II (elevated J'awNO), type III (elevated J'awNO and CANO) and type IV (elevated CANO). Correlation between fractional exhaled NO (FENO,50), J'awNO and CANO was studied using Spearman’s rho. Paired comparison were applied with Bonferroni's multiple comparison adjustment.Results: We studied 162 children; 49 (32.23%) were healthy and 103 (67.76%) asthmatic. J'awNO and CANO were reproducible. In controls FENO,50 (ppb) (median and range) was 11.5 (1.6-27.3), J'awNO (pl/s) was 516 (98.3-1470) and CANO (ppb) was 2.2 (0.1-4.5). Asthmatic subjects were classified: 44 (42.7%) in type I, 41 (39.8%) in type II, 14 (13.5%) in type III and 4 (3.88%) in type IV. Strong correlation was found between J'awNO and FENO,50. A significant increase was found in the number of exacerbations in type III and IV. There was no association between J'awNO and CANO.Conclusions: The results for CANO and J'awNO in healthy controls were similar to those found in other reports. There was no correlation between proximal and distal inflammation. Asthmatic patients with elevated CANO presented higher morbidity.