PT - JOURNAL ARTICLE AU - Elena Semenova AU - Marina Kameneva AU - Artem Tishkov AU - Vasiliy Trofimov AU - Lubov Novikova TI - Relationship the impulse oscillometry parameters and the lung damage in idiopathic pulmonary fibrosis patients DP - 2013 Sep 01 TA - European Respiratory Journal PG - P1284 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P1284.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P1284.full SO - Eur Respir J2013 Sep 01; 42 AB - Objective: to determine changes in the parameters of impulse oscillometry (IOS) in patients with idiopathic pulmonary fibrosis (IPF) and find their correlations with lung damage.Methods: 26 patients (54.46±9.9 yr) with IPF were tested with: IOS, spirometry, bodyplethysmography, measurement of diffusing lung capacity and compliance, computer tomography. In order to determine the stage of pathological process, the composite physiologic index (CPI) was used. Spearman correlation coefficient grater or equal then 0.6 was considered essential and significant at a p-value <0.05.Results: Patients with IPF had an increase of the resonance frequency (17.28±5.11, Hz), decrease of X5 (-0.19±0.12, kPa/l/s) and an increase in FD Rrs (0.11±0.08 kPa/l/s). Correlation analysis showed a significant negative correlation between ΔX5 and TLC, VC, RV, FEV1. A similar negative correlation was found between Rperipheral and VC, FEV1, TLC and DLCO. Positive correlation between X20Predicted and VC, positive correlation between X20 and VC, TLC, DLCO, and also between X5 and FEF25-75 were found. Analysis of IOS and CPI interconnections showed positive correlation between CPI and X5, CPI and Rperipheral, and negative correlation between CPI and X20.Conclusion: The decrease of the X5 and the increase of RF and FD Rrs characterize the group of patients with IPF, thus there is a strong correlation between some parameters of IOS and the index characterizing the restrictive alteration intensity and the extent of the pathological alternations in lungs. Increase of Rperipheral in patients with IPF is the indication of the deformation of small airways as the result of progression of pulmonary fibrosis.