RT Journal Article
SR Electronic
T1 Radiological findings and correlation to clinical outcome in patients admitted due to influenza A (H1N1) infection
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1893
VO 42
IS Suppl 57
A1 Beatriz Maria Jimenez Rodriguez
A1 Rosa Lina De los Santos López
A1 Julián Andrés Ceballos Gutierrez
A1 Irene Jimenez Rodriguez
A1 Bernardino Ancazar Navarrete
A1 Rosa Maria Ortiz Comino
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1893.abstract
AB OBJECTIVES: To examine whether radiological and clinical variables of patients hospitalized with H1N1 influenza infection are associated with disease severity and help predicting prognosis.MATERIAL: A retrospective observational study, which included patients hospitalized for influenza AH1N1 confirmed infection during 2009-2010, 2010-2011.Multivariate analysis was performed looking for variables that predicted the primary outcome (ICU admission and / or death during hospitalization), showing the results of the confidence intervals at 95% for the OR.RESULTS: during the study periods 98 patients with confirmed Influenza AH1N1 infection were admitted to our hospital, 16.3% requiring ICU admission and total hospital mortality of 6.1%. Regarding the radiological characteristics at admission, 26.8% had a normal study, 38.8% bilateral infiltrates and 24.5% unilateral infiltrates. Patients who met the primary outcome differed by a higher percentage of males, pregnant, bilateral infiltrates on admission, worse SpO2 and a higher percentage of complicated disease. Multivariate analysis showed that the only variable that was significantly associated with the outcome was the SpO2 (p< 0,001), with a trend toward statistical significance for unilateral infiltrates.Although fewer patients were diagnosed in the period 2010-2011, their condition was more serious according to SpO2, and up to 44% required admission to the ICU, compared with only 5.6% in the patients diagnosed during 2010-2011.CONCLUSIONS: Influenza AH1N1 infection associated with ICU admission and/ or mortality during hospital admission may be determined by the degree of respiratory failure present at the ED.