PT  - JOURNAL ARTICLE
AU  - Immanuels Taivans
AU  - Gunta Strazda
AU  - Normunds Jurka
AU  - Uldis Kopeika
AU  - Ainis Pirtnieks
AU  - Liga Balode
AU  - Maris Bukovskis
AU  - Agnese Kislina
AU  - Jevgenija Aprinceva
AU  - Liene Logina
TI  - Volatile organic compounds of exhaled breath in lung cancer and lung inflammatory diseases
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - 1823
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/1823.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/1823.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - BackgroundThe analysis of exhaled breath volatile organic compounds (VOCs) is a non-invasive diagnostic assay that could be applied for diagnosis of lung cancer.ObjectiveThe aim of our study was to measure the concentration of VOCs patients with lung cancer, COPD, pneumonia and in healthy volunteers.MethodsExhaled breath samples of 31 patient with lung cancer, 19 with COPD, 11 with pneumonia and 10 healthy volunteers were collected trough T-shape non-rebreathing valve into Tedlar bag system after 5 min. washout breathing of VOCs free air. VOCs concentration (ppb) was detected in gas chromatography/mass spectrometry and termodesorbtion device.ResultsConcentration of methanol, ethanol, dodecane and tridecane in breath samples of cancer patients was significantly lower than in patients with COPD, pneumonia and control group.View this table:Concentration of VOCs in exhaled breath of patients with lung cancer, COPD, pneumonia and control group (ppb)ConclusionsDifferent VOCs profile can in vivo discriminate patients with lung cancer, healthy patients and patients with inflammatory lung diseases.