TY - JOUR T1 - The possibility of using the level of concentration Fe2 + in the exhaled breath condensate as a diagnostic indicator in pulmonary pathology JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4273 AU - Elena Zaprudnova AU - Svetlana Soodaeva AU - Igor Klimanov AU - Timur Li AU - Lidiya Nikitina AU - Fedor Petrovskiy Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4273.abstract N2 - The aim was to study the level of concentration of Fe2+ in exhaled breath condensate of smokers compared with non-smokers during exercise, as well as in patients with bronchial asthma (BA).Methods. The control group consisted of healthy (those with no diagnosed respiratory disease), non-smokers aged 25 - 45 years. The second group included smokers aged 25 - 45 years old, diagnosed as those with no respiratory disease. Smoking history of 10 or more years. The third group consisted of non-smokers aged 25 - 45 years of age with asthma. Level of Fe2+ was determined by the ferrozin method at rest and after exercise (at a heart rate of 100-120 beats per minute) in both healthy and smokers than patients with asthma.Results. The study found that smokers there is an increase in the basal concentration of Fe2+ 2-fold in the lung tissue compared to healthy nonsmokers (p <0.05). Fe2+ content of smokers during exercise is 1.4 times higher than in non-smokers (p <0.05). BA patients also noted a change in the level of Fe2+ EBC. During exacerbation of asthma occurred increase in Fe2+ 1.6-fold compared with healthy subjects (p <0.05).Conclusion. Thus, the increase in Fe2+ in EBC may signal a change of free radical processes in the lungs, accompanied by the development of pathological processes in them. ER -