TY - JOUR T1 - Molecular pathway perturbations in pulmonary sarcoidosis JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P540 AU - Arsen Arakelyan Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P540.abstract N2 - This study is aimed at investigating pathomechanisms of pulmonary sarcoidosis (PS) based on evaluation of gene expression profiles in context of molecular pathways.We analyzed two PS microarray datasets publicly available in Gene Expression Omnibus using the algorithm called growing support sets-pathway signal flow (GSS-PSF) previously developed by us and molecular pathway maps from Kyoto Encyclopedia of Genes and Genomes (KEGG). GSS-SPF evaluates the changes in signal flows for a given pathway depending on the pathway topology and relative gene expression.The results of the data analysis are summarized in table 1.View this table:Table1. Deregulated pathways in PSOur findings are in line with the notion of PS pathogenesis. The “Fc-gamma receptor associated phagocytosis pathway” is implicated in granuloma formation, while the “Focal adhesion pathway” plays important role in biological processes including cell motility, proliferation and differentiation. The “Chemokine signaling pathway” showed upregulated signal flows leading to the activation of the “Leukocyte transendothelial migration pathway”, which is prerequisite for chemokine-induced immune cell infiltration into the lung. Comparison of pathway perturbations in self-limiting and progressive forms of PS showed that later is characterized by higher intensity of common pathological events.In conclusion, our study identified molecular pathways altered in PS and evaluated their functional outcomes. ER -