RT Journal Article
SR Electronic
T1 Risk of TB infection and smoking: IFN-γ concentration increases with the cigarettes' number in smokers
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P500
VO 42
IS Suppl 57
A1 Maria N. Altet-Gomez
A1 Jose Dominguez
A1 Maria Louisa de Souza
A1 Maria Angeles Jimenez
A1 Celia Milá
A1 Jordi Solsona
A1 Irene Latorre
A1 Angels Orcau
A1 Joan Cayla
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P500.abstract
AB Aims: Active and passive exposure to tobacco smoke are risk factors for TB infection, evidenced previously using Tuberculin Skin Test. We aim to determine the smoking influence on the TB infection in contacts of TB cases by means of IGRAs testing.Methods: 806 adults from contact tracing studies were included in the study. In all cases QFN-G-IT and TST were performed. The in vitro tests were performed following the manufacturer’s recommendations. We evaluate personal data and factors related with the TB contact.Results: Smoking was a TB infection predictive factor (Relative Risk (R.R): 1.92; 95% C.I: 1.65 – 2.23; p< 0.0000001). There was a significant tendency of the R.R with the number of cigarettes smoked daily and also with the concentration of IFN-γ released. Other predictive factors also were analyzed. Comparing smoking/ non smoking the association was significant in all the analyzed variables.View this table:Impact of Smoking on the TB infection Relative Risk (R.R). QFN-GIT concentration related with the cigarettes number smoked dailyConclusion. Using QFN-G-IT in contact tracing studies, smoking has been shown to be a risk factor for TB infection, avoiding the BCG interference on the TST. The IFN- γ concentration is on increase when the cigarettes’ number raises.