TY - JOUR T1 - Periostin as a marker of remodeling in young adults with clinical remission of asthma JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P584 AU - Sian Evans Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P584.abstract N2 - Background: Periostin, a novel marker of remodelling, has been shown to be overexpressed in the subepithelial region in asthmatic bronchial epithelial cells and is thought to play a part in the subepithelial fibrosis of asthma via its effects on collagen in the extracellular matrix of the bronchial lamina reticularis and submucosa. We aimed to compare Periostin as a marker of remodeling between young adults from the Isle of Wight 1989 Birth Cohort with persistent asthma n=11), asthma remission (n=15) and healthy controls (n=15).Methods: Bronchial biopsiy samples were analysed for Periostin deposition. Typically seen in the subepithelial region, percentage Periostin was measured in the area immediately beneath the epithelium to a depth of 100µm. Data was analysed using non-parametric methods.Results: Mean Periostin deposition in the submucosa was highest in those with persistent asthma, followed by those with asthma remission then healthy subjects. The difference between all three groups was significant (persistent asthma vs asthma remission p = 0.025, asthma remission vs healthy controls p = 0.007 and persistent asthma vs healthy controls p <0.001).Conclusion: Markers of remodelling are still visible in subjects with clinical remission of asthma. They have significantly higher levels of Periostin than healthy controls but less than those with persistent asthma. ER -