RT Journal Article
SR Electronic
T1 Multidrug-resistant tuberculosis in Czech Republic during the period of recent 5 years (2007-2012)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4461
VO 42
IS Suppl 57
A1 Veronika Polcová
A1 Emília Kopecká
A1 Martina Vasáková
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4461.abstract
AB BACKGROUND:Multidrug-resistant tuberculosis (MDR-TB) is defined as a resistance of Mycobacterium tuberculosis complex (MTB) to isoniazid and rifampicin at least.METHODS AND RESULTS:The aim of this retrospective study was to evaluate and compare a cohort of 37 patients with MDR-TB hospitalized in our specialized Unit for a treatment of MDR patients of the Czech Republic located in Prague in the years 2007 – 2012. We have evaluated the group of patients according to a birthplace, resistance type, clinical outcome, social profile, length of bacteriological positivity of sputum and length of hospitalization.14 of the patients (38%) were born in the Czech Republic (group A) and 23 (62%) were immigrants to the Czech Republic (group B). In cohort of 37 patients were 27 males (mean age 39 years) and 10 females (mean age 35 years). Primary resistance was present in 24 (65%) cases and in 13 (35%) cases secondary resistance. From social point of view there were 17 (46%) manual workers, 8 (21,6%) pensioners, 8 (21,6) unemployed, 4 (10,8%) refugees.There were 26 (70%) cured patients, ten (27%) remained on treatment, treatment faulire was noticed in 2 patients (5,4%), discontinuation of treatment in 1 patient (2,7%), and no patients died. The mean length of bacteriological positivity of sputum samples was 3,8 months and the mean length of hospitalization was 9,8 months.CONCLUSIONS:Prevalence of MDR TB cases in the Czech Republic has remained on the same level for several previous years compared to gradual increase in the world. If the number of immigrants from countries with high prevalence of tuberculosis to the Czech Republic will increase, the control of TB can be negatively influenced.