TY - JOUR T1 - In a general population there seems to be a link between subclinical atherosclerosis and lung hyperinflation JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3440 AU - Alexander Lorenzo Hartmann AU - Robab Breyer-Kohansal AU - Marie-Kathrin Breyer AU - Sylvia Hartl AU - Andrea Schrott AU - Otto Chris Burghuber Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3440.abstract N2 - BackgroundIn patients with COPD it has been shown that there is a correlation between the degree of lung hyperinflation and subclinical atherosclerosis measured by carotid-femoral PWV (pulse wave velocity-PWV). We wondered wheter we could demonstrate this correlation also in a general population cohort.MethodsIn an interim analysis of the ongoing Austrian LEAD (Lung hEart sociAl body) study, a single-center, longitudinal, open labeled, observational, population based cohort study, 1147 participants were included (female 54,9%, mean age 52,8 yrs). In addition to PWV also age, parameters of lipid profil (HDL plasma level), systemic inflammation (hsCRP), and lung hyperinflation (RV%/TLC) were measured.ResultsIn total 7,2% (n=83) of participants showed elevated levels of PWV, defined as > 12m/second indicating subclinical atherosclerosis. Compared to participants with normal PWV, those with elevated PWV were older (67,2+/-8,0 vs 51,7+/-15,7; p=0.0051), had higher HDL plasma levels 67,3mg/dl+/-18,6 vs. 62,1mg/dl +/-16,9; p=0.05), higher hsCRP plasma levels (3,2mg/dl +/- 4,4 vs. 2,1mg/dl +/-3,9; p=001), and increased RV%TLC post lysis (40,8% +/-6,8 vs. 34,9%+/-7,7;p=0.000). However, in a multivariant analysis, only age correlated significantly with PWV, possibly due to the small sample size.ConclusionIn a general population cohort, subclinical atherosclerosis seems not only be linked to age, lipid profil and systemic inflammation, but also to lung hyperinflation. ER -