TY - JOUR T1 - Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: The HUNT study JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3438 AU - Tricia L. Larose AU - Arnulf Langhammer AU - Yue Chen AU - Carlos A. Camargo, Jr. AU - Pål Romundstad AU - Xiao-Mei Mai Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3438.abstract N2 - The association between vitamin D deficiency and pulmonary function in adults with asthma remains unclear.The objective was to determine the association between vitamin D deficiency [serum 25(OH)D <50nmol/L] and pulmonary function in an adult asthma cohort, and to explore possible effect modification by sex and allergic rhinitis.This cross-sectional study included 760 asthmatic adults aged 19-55 years, who participated in the second Nord-Trøndelag Health Study (HUNT2). Lung function measures included percent predicted (pp) FEV1, ppFVC, and FEV1/FVC ratio. We used multiple linear regression to calculate point estimates and 95% confidence intervals (CI).Overall, 44% of the asthmatic adults were vitamin D deficient. Vitamin D deficiency was significantly associated with lower ppFEV1 (-8%, 95% CI: -14% to -3%) and lower FEV1/FVC ratio (-5%, 95% CI: -9% to -1%) in men after adjustment for potential confounders. When further stratified by allergic rhinitis, the association between serum 25(OH)D and FEV1/FVC ratio was significant in men without allergic rhinitis (-11%, 95% CI: -22% to -1%), but not in men with allergic rhinitis (-3%, 95% CI: -9% to 2%) (p value for interaction: <0.1). The association in women was not significant overall or by allergic rhinitis. Similar results were found when serum 25(OH)D was analysed as a continuous variable.Vitamin D deficiency was not significantly associated with pulmonary function in most adults with asthma, with the exception of asthmatic men without allergic rhinitis. ER -