RT Journal Article
SR Electronic
T1 Tobacco exposure and asthma control in pregnancy: A prospective observational study of 500 pregnancies
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2020
VO 42
IS Suppl 57
A1 Pernille Grarup
A1 Julie Janner
A1 Charlotte Suppli Ulrik
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2020.abstract
AB Background and Aim: Asthma and tobacco exposure is common among pregnant women. We investigated the effect of passive and active tobacco exposure on asthma control during pregnancy. Methods: Prospective observational design. Primary outcome was episodes of uncontrolled asthma during pregnancy. Patients had their asthma control, tobacco exposure, spirometry and exhaled nitric oxide assessed during regular visits. Results: A total of 500 pregnant women with asthma (defined according to GINA-guidelines) aged 17 to 44 years were included, of whom 32 (6.4%), 115 (23.0%) and 353 (70.6%) were current smokers, ex-smokers and never smokers, respectively. Sixty-five patients (13.0%) reported passive tobacco exposure. Current and ex-smokers had significantly lower FEV1%pred compared with never smokers (p<0.05).The relative risk of an episode of uncontrolled asthma during pregnancy was 4.5 (95% CI 2.7 – 7.5: p<0.001) in current and ex-smokers compared with never smokers, and 2.9 (95% CI 1.4 – 5.9; p=0.004) in women with passive tobacco exposure compared with women not reporting passive tobacco exposure. Conclusion: Not only active smoking, but also passive tobacco exposure is associated with an increased risk of episodes of uncontrolled asthma during pregnancy.