RT Journal Article
SR Electronic
T1 Serum vitamin D levels are associated with markers of hypoxia in obstructive sleep apnea patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P317
VO 42
IS Suppl 57
A1 Evangelia Nena
A1 Kostas Archontogeorgis
A1 Maria Xanthoudaki
A1 Panagiotis Boglou
A1 Andreas Koulelidis
A1 Theodore Constantinidis
A1 Marios Froudarakis
A1 Athanassios Zisimopoulos
A1 Demosthenes Bouros
A1 Paschalis Steiropoulos
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P317.abstract
AB Background: Vitamin D (Vit. D) insufficiency has been associated with metabolic syndrome, diabetes and cardiovascular disease, conditions also related with obstructive sleep apnea syndrome (OSAS).Aim of the study was to examine serum levels of Vit. D in otherwise healthy OSAS patients and to explore associations between these levels and patients' sleep and anthropometric characteristics.Methods: Patients with polysomnographically confirmed OSAS (AHI>15/h) were included. To all of them blood was drawn in order to examine Vit. D levels with radioimmunoassay (RIA). Additionally, PFTs and ABGs analysis were conducted.Results: Totally, 136 patients (94 males) with mean AHI 59.1/h, minimum SpO2 67.8±11.4%, and average SpO2 89±3.5% were included. PFTs and ABGs results were within normal range.Mean levels of Vit. D were 19.5±10.9 ng/ml. These levels were positively correlated with Total Sleep Time (p=0.003), Sleep Efficiency (p=0.008), S2%TST (p=0.006), and negatively with S1%TST (p=0.010). Additionally, a negative association was revealed with AHI (p=0.039), maximum apnea duration (p=0.001), and t<90% (p=0.004), and a positive association with averSpO2 (p=0.001) and minSpO2 (p=0.004) during sleep and PaO2 (p=0.003). No association was found with age or BMI.OSAS patients with hypovitaminosis D (<20 ng/ml) had significantly lower minSpO2 (p=0.022) and PaO2 (p=0.010) levels, and higher maximum apnea duration (p=0.025) and t<90% (p=0.049), in comparison to patients with Vit. D >20ng/ml.Conclusions: Vit. D levels are negatively affected by OSAS. This association could be considered in interpreting the pathogenesis of cardiovascular and metabolic disorders in OSAS.