TY - JOUR T1 - Association between obstructive sleep apnea (OSA) and cancer incidence - A nationwide population-based study JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4014 AU - Po-Ju Wei AU - Ming-Ju Tsai AU - Yi-Hsuan Tsai AU - Tzu-Yu Kuo AU - Chia-Min Chen AU - Ming-Shyan Huang Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4014.abstract N2 - RationaleRecently, increased incidence of cancer in patients with severe OSA has been reported from a large multicenter Spanish cohort. Therefore, we conducted a nationwide population-based study using Taiwan National Health Insurance (NHI) database.MethodsThe dataset used for this study is a cohort of 1 million subjects randomly sampled from individuals enrolled in the NHI system. We enrolled patients, aged 18∼80 years, with a diagnosis of OSA by polysomnography (PSG) in the dataset. Patients had a diagnosis of cancer prior to OSA were excluded. The first day of OSA diagnosis was defined as the index day. Each patient was matched to 25 randomly-selected, age- and gender-matched control subjects without OSA. The control subjects were given the same index day as their matched case. The occurrance of cancer was identified from the catastrophic disease claim dataset.ResultsFrom the dataset, a total of 2064 patients with a diagnosis of OSA by PSG were identified. After excluding patients by algorithm and matching to control subjects, 1189 patients and 29661 control subjects were identified for further analysis. Between OSA patients and control subjects, the cancer incidence and the free-from-cancer survival curve showed no significantly difference.ConclusionsThe previous study showed increased cancer incidence in severe OSA patients compared with OSA patients with low apnea-hypopnea index. However, difference between OSA and non-OSA group was not discussion. Our study revealed no significantly difference in cancer incidence between these two groups, but we could not identify the severity of OSA. Further study may be needed to identify the association between OSA and cancer. ER -