RT Journal Article SR Electronic T1 Effect of 3-month CPAP treatment on blood pressure and serum aldosterone concentration in patients with resistant hypertension JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P307 VO 42 IS Suppl 57 A1 Patricia Lloberes A1 Gabriel Sampol A1 Eugenia Espinel A1 Alfons Segarra A1 M. Ferrer A1 Odile Romero A1 Maria Jose Jurado A1 M. Antonia Ramon A1 Dolores Untoria A1 Miguel Angel Martinez Garcia YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P307.abstract AB Introduction: The role of the renin-angiotensin-aldosterone system (RAAS) on the association obstructive sleep apnea (OSA) and resistant hypertension (RH) is unclear. Aim: To analyze the effect of CPAP on 24-h blood pressure monitoring (ABPM) and on serum aldosterone in RH patients. Methods: 102 patients with an OSA15 and office-RH were randomized to CPAP (n=50) or to conventional treatment (n=52) for 3 months. 24-h ABPM and serum aldosterone were measured. 78 patients completed the follow-up (36 CPAP, 42 conventional treatment). Results: 66.7% were male, aged 58.27±9.3yrs and AHI 50.1±21.6, without significant differences between both groups. Serum aldosterone and AHI correlated significantly in patients with ABPM-confirmed RH (r= 0.25, p=0.02). CPAP achieved a significant decrease in serum aldosterone and 24-h BP decreased especially in those with ABPM-confirmed RH.View this table:Effects of 3-month treatment on 24-h BP and serum aldosterone in patients with ABPM-confirmed resistant hypertension, randomized to conventional treatment or to CPAPConclusion: The association between OSA and RH could be mediated at least in part by an effect on the RAAS.