TY - JOUR T1 - Survival of mesothelioma patients after radical extrapleural pneumonectomy in the Nancy Biobank's database JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3074 AU - Fotis Vlastos AU - Georgios Kaltsakas AU - Jean-Michel Vignaud AU - Nadine Martinet Martinet AU - Nickolaos G. Koulouris Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3074.abstract N2 - Radical extrapleural pneumonectomy (EPP) entails the complete removal of the ipsilateral lung along with the parietal pleura, pericardium and the majority of the hemidiaphragm. The Nancy “Centre of Biologic Resources” (“Centre des Ressources Biologiques”) is an ISO 9001–2000 certified biobank with biologic material and follow-up data from French lung cancer and mesothelioma patients, collected for the last 20 years. This allows for a survey of mesothelioma survival rates and impact of EPP. Therefore, we set out to investigate whether EPP can increase the survival in mesothelioma patients comparing to chemotherapy.Clinical and occupational data from 190 consecutive mesothelioma patients who underwent EPP, only chemotherapy, and palliative care were collected from the Nancy Database. Twenty seven of the patients underwent EPP (n=9 only EPP, Group A; n=16 EPP and chemotherapy, Group B; n=1 EPP and radiotherapy; n=1 EPP, chemotherapy, and radiotherapy). One hundred four patients had chemotherapy (Group C). Fifty nine patients had palliative care (Group D).The patients underwent EPP had mean survival time (SD±SE, months) 20.0±3.3. Group A had mean survival time 16.8±3.9. Group B had mean survival time 19.3±3.9. Group C had mean survival time 25.9±2.8. Group D had mean survival time 10.8±1.4. The survival curves of Group B and Group D were significant different (p=0.029). The survival curves of Group C and Group D were significant different (p<0.001). The survival curves of Group A or Group B were not significant different from Group C.EPP does not appear to increase the survival of mesothelioma patients compared to chemotherapy. ER -