TY - JOUR T1 - Hemodynamic assessment of patients with pulmonary hypertension due to lung disease and/or hypoxia JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2637 AU - Mario Gerges AU - Christian Gerges AU - Marie Lang AU - Irene Lang Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2637.abstract N2 - PURPOSE: Current guidelines classify PH due to lung disease and/or hypoxia (group 3) as pre-capillary PH (mean pulmonary artery pressure (mPAP) ≥25mmHg and mean pulmonary capillary wedge pressure (mPCWP) ≤15mmHg). In the setting of lung disease, multiple mechanisms of disease play a role apart from classical pulmonary arteriopathy, hypoxia, hypercapnia, mechanical stress of hyperinflated lungs, emphysematous and fibrotic changes, inflammation and toxic effects of cigarette smoke. We hypothesized that a significant proportion of patients with PH due to lung diseases carries a post-capillary component.METHODS: A large database (n=3107) of right and left heart catheterizations was interrogated.RESULTS: Of 291 patients with PH due to lung disease, 96 patients had normal hemodynamics (“Non-PH” mPAP<25mmHg). Of the remaining 195 patients with PH, 53 were classified as pre-capillary PH (mPCWP ≤15mmHg), and 142 had elevated left ventricular filling pressures (mPCWP >15mmHg). Multivariate analysis identified stable ischemic heart disease as an independent predictor of survival (p=0.014).View this table:Table 1. Age and hemodynamic characteristics of patients with pulmonary hypertension due to lung disease and/or hypoxiaCONCLUSION: The data demonstrate that a significant proportion of patients with PH due to lung disease suffers from post-capillary pulmonary hypertension. ER -