TY - JOUR T1 - Hypersensitivity skin-prick test with common allergens, immunoglobulin E level and their genetic association with interleukin 13 among asthmatics in Sudan JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3155 AU - Amel Gundi AU - Omer Musa AU - Muntasir Ibrahim AU - Hiba Salah Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3155.abstract N2 - Background:Atopy, the genetic predisposition for the development of an immunoglobulin (IgE). It is assessed by positive skin-pricktest responses. The triggering factors in Sudanese were found to be house dust,molds, smoke, and pollens (Bashir and Musa, 2003; Magzoob et al., 2012).Objective:To estimate IgE level and investigate the degree of association of common allergens found in Sudan among asthmatics, and their association with IL13 gene.Methods: The study is a family based, a total of 52 Sudanese multi case families were included (cases 141 and controls 129). Skin prick tests were done using different aeroallergens (A panel of thirteen inhalants) found to be common in Sudan. IgE level was measured. IL13 gene was genotyped using PCR.Result:Hypersensitivity to most allergens could be detected in the majority of asthmatics(P values range 0.001- 0.01),these include;house dust,mixed molds,D. Peterenyssinus, mixed ragweed, grass pollens, and cat hair.85.3%(110/141) of asthmatics showed positive SPT to mixed molds. Asthmatics with positive SPTs showed higher IgE levels as well 75.2 % (106), which also consistent with hypersensitivity symptoms(p = 0.001).High IgE level was observed among asthmatic (p= 0.001).Significant association of IL13gene(A-646G) polymorphism with asthma status (p =0.008),IgE (p =0.008) and SPTs (p = 0.02) was observed among asthmatics.IL13gene, skin tests, IgE and asthmaConclusion: Asthmaticsin Sudan showed hypersensitivity to common aeroallergens. There is correlation between positive SPTsand high IgE levels inasthmatics. There is strong genetic correlation between IL13 gene, skin tests, IgE and asthma. ER -