PT - JOURNAL ARTICLE AU - Ines Neves AU - Susana Guimaraes AU - Conceiçao Souto Moura AU - Filipa Soares Pires AU - Ana Paula Vaz AU - Pedro Bastos AU - Henrique Queiroga AU - Venceslau Hespanhol AU - Gabriela Fernandes TI - Does IASLC/ATS/ERS classification of lung adenocarcinoma impacts prognosis? DP - 2013 Sep 01 TA - European Respiratory Journal PG - P2917 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P2917.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P2917.full SO - Eur Respir J2013 Sep 01; 42 AB - Background: IASLC/ATS/ERS classification provides a uniform approach to categorize lung adenocarcinoma (AC) subtypes which may have a distinct clinical behavior.Objective: To identify clinical characteristics and prognostic impact of the new IASLC/ATS/ERS classification in patients with resected lung AC.Methods: IASLC/ATS/ERS classification in resections specimens was reviewed in patients who underwent resection of lung AC between 1999 and 2012. The impact of AC pattern in disease-free (DFS) and overall survival (OS) was determined.Result: 150 patients were included, 66% male, median age 65 years and 57.3% smokers. Median DFS was 38 months and OS was 76 months. AC patterns were: acinar predominant 44.7%, solid predominant 22.0%, papillary predominant 12.0%, lepidic predominant 3.3%, invasive mucinous 3.3%, two equally predominant patterns 9.4%, no cases of micropapillary predominant and 5.3% were not possible to reclassify. Lepidic predominant was significantly associated to female and non-smoker patients, smaller tumor size (<3mm) and lower pathological T (p= 0.018, 0.042 and 0.026, respectively). Solid predominant was significantly associated to male gender and smoking habits (p=0.007 and 0.027, respectively). Other patterns didn’t show significant associations.AC patterns were not associated to DFS. The 5-year OS in lepidic predominant was 100%, acinar predominant 66%, papillary predominant 59%, invasive mucinous 55% and solid predominant 50%. These differences were not statistically independent of the pathological TNM.Conclusion: IASLC/ATS/ERS classification of lung AC identifies morphologic patterns seem to be associated with distinct clinical, pathological and prognostic characteristics.