TY - JOUR T1 - Changes in the populations of blood T-lymphocytes containing chemokine receptors in non-smoking patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3897 AU - Aliaksei Kadushkin AU - Anatoliy Tahanovich AU - Tatiana Shman Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3897.abstract N2 - Background. Chemokine receptors are considered to play an important role in regulating the migration of immune cells, including T-cells, from the peripheral blood into inflamed tissue, such as the lung. However their role has not been studied in non-smoking patients with chronic obstructive pulmonary disease (COPD).Aim. The aim of the study was to determine the percentage of CD3+CXCR3+ and CD3+CCR5+ lymphocytes in blood of COPD patients.Methods. For analysis of lymphocytes subtypes the flow cytometry method was used. The study population consisted of 21 non-smokers with COPD, 20 smokers with COPD, 20 healthy non-smokers and 21 healthy smokers.Results. There were no significant differences in the proportion of T-cells (CD3+) between the groups. We observed an increase in blood T-cells expressing receptors CXCR3 and CCR5 in non-smokers with COPD compared with healthy non-smokers (CXCR3+ T-cells: median value was 46.2% vs 36.6%, respectively, p<0.05; CCR5+ T-lymphocytes: 5.2% vs 2.7%, respectively, p<0.001). The percentage of T-cells containing receptors CXCR3 and CCR5 was significantly higher in blood of smokers with COPD when compared to healthy smokers (CXCR3+ T-lymphocytes: median value was 40.5% vs 37.3%, respectively, p=0.001; CCR5+ T-cells: 4.6% vs 3.1%, respectively, p<0.05). No differences were seen in the proportion of CD3+CXCR3+ and CD3+CCR5+ lymphocytes between COPD smokers and COPD non-smokers.Conclusion. Our findings suggest a similar mechanism of T-cells migration from blood into the airways in non-smoking and smoking COPD patients. ER -