PT  - JOURNAL ARTICLE
AU  - Daisy Janssen
AU  - Alvar Agusti
AU  - Hana Müllerova
AU  - Julie Yates
AU  - Ruth Tal-Singer
AU  - Stephen Rennard
AU  - Jorgen Vestbo
AU  - Emiel Wouters
TI  - The relationship between persistent systemic inflammation and symptoms of depression among patients with COPD in the ECLIPSE cohort
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - 4851
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/4851.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/4851.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: Depression is highly prevalent among patients with Chronic Obstructive Pulmonary Disease (COPD). The relationship with systemic inflammation remains unknown. Objective of this observational study is to compare depression scores at baseline and three years in COPD patients with and without persistent inflammation.Methods: ECLIPSE study included 2164 COPD patients. Demographics, clinical characteristics and symptoms of depression (Center for Epidemiologic Studies of Depression, CES-D) were measured at baseline and 36 months. Persistent inflammation was defined as ≥2 of the biomarkers: white blood cell count, hsCRP, IL-6, and fibrinogen in the upper quartile at baseline and 12 months.(Agusti et al. 2012).Results: 1349 patients (age 63.1 (7.0) yrs; 65.2% male; FEV1 49.6 (15.3)% pred.; 10.2% persistent inflammation; SGRQ-C 47.9 (19.9) pts) had complete data. At baseline, mean CES-D score was higher among patients with persistent inflammation than patients without (12.9 (9.4) vs. 10.4 (9.0), p=0.002). Linear regression analysis did not confirm this relationship (beta -0.002, p=0.94). Age, sex, mMRC, SGRQ-C, and Functional Assessment of Chronic Illness Therapy (FACIT) fatigue subscale were related with CES-D scores (adjusted p<0.05). CES-D scores at 36 months were comparable between patients with and without inflammation (12.8 (9.4) vs. 11.8 (9.3), p=0.21). Changes in CES-D score were also comparable in patients with and without inflammation (0.0 (9.6) vs. 1.4 (8.4), p=0.06).Conclusions: The ECLIPSE study did not show a relationship between persistent inflammation and symptoms of depression at baseline and after 3 years among patients with COPD.