PT  - JOURNAL ARTICLE
AU  - Nina Karoli
AU  - Gulnara Dolishnyaya
AU  - Andrey Rebrov
TI  - 24-hour arterial stiffness monitoring values in patients with COPD
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P1867
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P1867.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P1867.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Purpose. The aim of the study was analysis of twenty-four-hour arterial rigidity (AR) monitoring values in patients with chronic obstructive pulmonary disease (COPD) in different stage of disease with arterial hypertension (AH).Methods. The study included 58 male patients with COPD and AH. Mean age was 63.3±8.9 years. Duration of disease was 7.5±5.7 years for COPD and 5.8±5.7 years for AH. All patients were divided into three groups. There were 18 patients with moderate COPD, 21 patients with severe COPD and 19 patients with very severe obstruction. Comparison group included 50 male patients with essential AH without chronic respiratory diseases, control group - 22 healthy male individuals. Twenty-four-hour AR monitoring measurement was performed using BPLab® MnSDP-2 apparatus (Petr Telegin, Russia). For assessment of AR we used pulse transit time (PTT2), (dP/dt)max and augmentation index (AIx) indexes. Values of AIx less than -10% a normal, and values greater than or equal to -10% are pathological.Results. In patients with severe and very severe COPD significant decrease of PTT2 index, increase of AIx versus patients of comparison group and control subjects have been observed (p<0.001). We observed significant lowering of PTT2 at nighttime in main group in comparison with other clinical series (p<0.01). Mean AIx value during nighttime in all patients with COPD was significantly higher than during daytime value. There is prevalence of abnormal AIx during 24-hour monitoring.Conclusion. Pronounced increasing of AR is most common in patients with severe and very severe COPD. We observed circadian variation of AR parameters with prevalence of nocturnal abnormality.