TY - JOUR T1 - Validation of the four -variable screening tool in a European population for assessing obstructive sleep apnea syndrome JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2034 AU - Athanasia Pataka AU - Nikolaos Chavouzis AU - Katalin Fekete Passa AU - Asimina Paspala AU - Evdokia Sourla AU - Eleni Vaitsi AU - George Kalamaras AU - Georgia Pitsiou AU - Vasilios Bagalas AU - Ioannis Stanopoulos AU - Paraskevi Argyropoulou Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2034.abstract N2 - Background: The 4-Variable screening tool (4-V) was developed and validated in Japan from Takegami et al as a tool for the identification of Obstructive Sleep Apnea Syndrome (OSAS).Objectives: To evaluate the ability of the 4-V to estimate the incidence of OSAS as measured by Apnea Hypopnea Index (AHI) in a European Population as the antropometric data differ between race (caucasian-asian).Methods: The risk of OSAS was calculated by the 4-V tool in 1057 patients visiting a sleep clinic in Greece. All patients underwent polysomnography (PSG).Results: The mean age of patients (73.8%male) was 52±14 yr, BMI 32.9±7 kg/ m2, neck circumference 41.75±4.3 cm, Epworth Sleepiness Scale (ESS) 11.5±5.4, Apnea Hypopnea Index (AHI) 32.7±26.5/h, Oxygen Desaturation Index (ODI) 37.7±29.6 and 4-V score 13.3±2.5. OSAS was diagnosed with PSG in 849(80.3%) patients: 13.6% mild, 19.1% moderate,47.6% severe. By 4-V (≥14) 45.1% (477) of patients were classified as being at high risk of OSAS. The sensitivities of 4-V for AHI ≥5, ≥ 15 and ≥ 30 were 50.7%, 54.9% and 61%, respectively; the specificities 78%,74.4%,69.3%; the positive predictive values 90.3%, 81.1%, 64.3%; the negative predictive values 27.9%, 45.1% and 66.2%. The area under the ROC curve at AHI≥ 5 was 0.68.Conclusions: In a European population 4-V may miss cases suffering from OSAS (relatively low sensitivity) but it has good specificity classifying fewer normal persons as high-risk for OSAS. ER -