PT  - JOURNAL ARTICLE
AU  - Divya Mohan
AU  - Carmel McEniery
AU  - Nicola Gale
AU  - Jonathan Fuld
AU  - Charlotte Bolton
AU  - William MacNee
AU  - Peter Calverley
AU  - Ruth Tal-Singer
AU  - Ian Wilkinson
AU  - Michael Polkey
AU  - John Cockcroft
TI  - ERICA (<span class="underline">e</span>valuating the <span class="underline">r</span>ole of <span class="underline">i</span>nflammation in <span class="underline">c</span>hronic <span class="underline">a</span>irways disease): Extrapulmonary manifestations of COPD
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - 4848
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/4848.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/4848.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - IntroductionERICA is a longitudinal study investigating the significance of cardiovascular (CV) and skeletal muscle (SM) manifestations of COPD and fibrinogen in relation to death/admission. This midpoint analysis asks whether the CV & SM manifestations represent the same patient subsets.MethodWe measured blood pressure (BP), spirometry, fibrinogen, 6 min walk distance (6MW), quadriceps maximal voluntary contraction force (MVC), and aortic pulse wave velocity (PWV). We defined CV manifestation as PWV>10m/s (EHJ 2010;31: 2338) and SM weakness as MVC/BMI ratio<1.2 (Thorax 2007 62:115).ResultsTable 1 presents data from the first 318 of a planned 800 patients, grouped according to presence of CV and/or SM manifestations, with Group 1 (SM) N=95, Group 2 (CV & SM) N=80, Group 3 (neither CV/SM) N=78 and Group 4 (CV) N=65 (Fig 1).View this table:Table 1ConclusionAnalysis of data from COPD patients enrolled in ERICA thus far suggests that there are distinct CV and SM subsets.