%0 Journal Article %A Divya Mohan %A Carmel McEniery %A Nicola Gale %A Jonathan Fuld %A Charlotte Bolton %A William MacNee %A Peter Calverley %A Ruth Tal-Singer %A Ian Wilkinson %A Michael Polkey %A John Cockcroft %T ERICA (evaluating the role of inflammation in chronic airways disease): Extrapulmonary manifestations of COPD %D 2013 %J European Respiratory Journal %P 4848 %V 42 %N Suppl 57 %X IntroductionERICA is a longitudinal study investigating the significance of cardiovascular (CV) and skeletal muscle (SM) manifestations of COPD and fibrinogen in relation to death/admission. This midpoint analysis asks whether the CV & SM manifestations represent the same patient subsets.MethodWe measured blood pressure (BP), spirometry, fibrinogen, 6 min walk distance (6MW), quadriceps maximal voluntary contraction force (MVC), and aortic pulse wave velocity (PWV). We defined CV manifestation as PWV>10m/s (EHJ 2010;31: 2338) and SM weakness as MVC/BMI ratio<1.2 (Thorax 2007 62:115).ResultsTable 1 presents data from the first 318 of a planned 800 patients, grouped according to presence of CV and/or SM manifestations, with Group 1 (SM) N=95, Group 2 (CV & SM) N=80, Group 3 (neither CV/SM) N=78 and Group 4 (CV) N=65 (Fig 1).View this table:Table 1ConclusionAnalysis of data from COPD patients enrolled in ERICA thus far suggests that there are distinct CV and SM subsets. %U https://erj.ersjournals.com/content/erj/42/Suppl_57/4848.full.pdf