RT Journal Article
SR Electronic
T1 Comparison of British and American Thoracic Societies' reintroduction guidelines for anti-tuberculous therapy induced liver injury
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1606
VO 42
IS Suppl 57
A1 Faisal Faiyaz Zuberi
A1 Bader Faiyaz Zuberi
A1 Nimrah Bader
A1 Syed Khalid Ali
A1 Farhana Mumtaz
A1 Tehseen Fatima
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1606.abstract
AB Background: There are many different guidelines for reintroduction of anti-tuberculous therapy (ATT) after drug induced liver injury (DILI)Aims & Objective: This study was designed to compare two reintroduction regimes as advised by British Thoracic Society (BTS) and American Thoracic Society (ATS) in terms of efficacy.Methods: Patients of either sex of age 18-60 years who develop DILI after ATT were selected after informed consent. Patients were randomly allocated to two groups, Group-I (BTS) received reintroduction as H = 100mg/day from day 1, maximum dose from day 4; R = 150 mg/day from day 8, maximum from day 11; and Z = 500 mg/day from 15, maximum from day 18. Group-II (ATS) received reintroduction as R = maximum dose from day 1, H = maximum dose from day 8, Z maximum dose from day 15.Relapse rates were compared using χ2 test. ROC curve were plotted for DILI recurrence with age, BMI and albumin. P value of <0.05 was taken as significant.Results: Total of 326 patients were selected, ATT was reintroduced as per Group allocation. Recurrence of DILI was seen in 34 (10.4%) patients out of which 16 (9.8%) were from Group-I while 18 (11.1%) were from Group-II (p = 0.72). ROC plot showed significant area under curve for BMI and albumin for recurrence of TB DILI with area under curve for BMI and albumin of 0.953 and 0.988 respectively.Conclusion: There is no significant difference in recurrence of TB DILI by either recommended guidelines of BTS and ATS.