@article {Edvardsen369, author = {Elisabeth Edvardsen and Ole Henning Skjonsberg and Fredrik Borchsenius and Sigmund A. Anderssen}, title = {Effect of training on maximal oxygen uptake and muscular strength after lung cancer surgery - A randomized controlled trial}, volume = {42}, number = {Suppl 57}, elocation-id = {369}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background: Lung cancer surgery may result in severe deconditioning, having a negative effect on their daily life activity. The effect of physical training following lung resection has not been thoroughly investigated. The aim was to study the effect of a training program after surgery in lung cancer. The primary outcome was change in maximal oxygen uptake (VO2max) and secondary outcomes included change in muscular strength and total muscle mass.Methods: The effect of supervised endurance- and strength training program (60 min three times a week for 20 weeks) in 62 lung cancer patients (female=31) were studied during a single-blind, randomized controlled trial 5-7 weeks after surgery. The control group received standard post-operative care. VO2max was directly measured on a treadmill. Muscular strength was assessed by measuring explosive and endurance strength, and muscle mass was measured by DXA-scan.Results: Of the 55 patients who fulfilled the intervention, the 25 in the training group had a significant improvement in VO2max from19.2{\textpm}5.15 to 23.3{\textpm}5.2 ml{\textbullet}kg-1{\textbullet}min-1 (p\<0.001), compared to 18.1{\textpm}5.5 to 19.5{\textpm}6.0 in the control group (p=0.269). The difference between the groups was 17 \% (p=0.003). The corresponding differences between the groups in strength measurements were; 1RM Leg Press, 23 \% (P\<0.001), Chair Stand, 20 \% (P\<0.001), Stair Run for 15 seconds, 12 \% (P=0.013), total muscle mass, 3 \% (P=0.009).Conclusion: In newly resected lung cancer patients, hard training was well tolerated and resulted in a significant increase in VO2max and muscular strength compared to controls. This study may form a basis for exercise therapy after lung cancer surgery.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/369}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/369.full.pdf}, journal = {European Respiratory Journal} }