TY - JOUR T1 - Measuring properties of different dyspnea instruments in sarcoidosis JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P420 AU - Branislav S. Gvozdenovic AU - Violeta Vucinic AU - Mira Vukovic Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P420.abstract N2 - The aims of the study were to determine the cut-off values of different dyspnea measuring scales in sarcoidosis patients, and to find the scale that best correlates with the degree of fatigue.In the case-control study the degree of dyspnea and fatigue were measured in 131 sarcoidosis patients and the same number of healthy volunteers. Dyspnea was assessed by Modified MRC Dyspnea Scale, Borg Category Scale (BCS) and the List of Daily Activities (DAL). Fatigue was measured by standardized Fatigue Scale (FS). The criterion for increased fatigue was the Total Score ≥3 (from response options 1 to 4). Discriminatory power of individual variables of dyspnea between healthy volunteers versus sarcoidosis patients was evaluated using the ROC (receiver operating characteristic) procedures. Relationship of new categorical variables of dyspnea (presence/absence) and a categorical variable of Total FS score in a population of sarcoidosis patients was estimated by Phi method.We found that for all three examined dypnea scales cut-off values for the increased dyspnea is 0/1. Sensitivity in the detection of dyspnea for Scores of MRC, BCS and DAL was 0.664, 0.718 and 0.855 respectively, and specificity 1.00, 0.952 and 0.810 respectively. For all dyspnea scales areas under the curves were highly significant (the biggest was for DAL Score – 0.889). The highest correlation of newly formed dichotomy categorical dyspnea variables with Total score of FS existed with BCS scores (Phi=0.401, p<0.0001); with MRC and DAL scores it was lower (Phi=0.382, p<0.0001 and Phi=0.298, p<0.0001; respectively).Borg category scale can best detect the presence of increased dyspnea that largely correlates with fatigue presence in sarcoidosis patients. ER -