TY - JOUR T1 - Adenosine deaminase for diagnosis of pleural tuberculosis in intermediate-low prevalence scenarios JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P514 AU - Alberto Garcia-Zamalloa Osakidetza AU - Jorge Taboada Osakidetza Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P514.abstract N2 - OBJECTIVE: To assess the diagnostic value of ADA for pleural TB in intermediate-low prevalence scenariosMETHODS: We reviewed all patients with pleural effusion from January 1998 to December 2011. ADA value and lymphocyte proportion were determined in all samples. We distinguished confirmed and probable TB following international criteria. ADA 40 U/l and LP 50% were defined as cut-off values.RESULTS: 607 episodes of pleural effusion were analysed, 93 cases (36 confirmed and 57 probable) were tuberculous (15%). Mean ADA value of both groups were 59 and 64 U/l respectively. On the whole period, ADA40 and LP50 showed a sensitivity, specificity, PPV and NPV of 88%, 98%, 89% and 97%. Area under the curve was 0.97 (95% IC 0.95-0.99).Corresponding values of periods 1998-2003 and 2004-2011 are contained in Table 1 and 2.View this table:Table 1: Bayesian probabilities of test parameters used. 1998-2003View this table:Table 2: Bayesian probabilities of test parameters used. 2004-2011CONCLUSIONSADA remains useful in intermediate-low prevalence scenarios. ER -