TY - JOUR T1 - Serum heat shock protein 47 levels in patients with drug induced lung diseases JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P5125 AU - Tomoyuki Kakugawa AU - Shin-ichi Yokota AU - Yuji Ishimatsu AU - Shota Nakashima AU - Shintaro Hara AU - Noriho Sakamoto AU - Hiroshi Kubota AU - Mariko Mine AU - Yasuhiro Matsuoka AU - Hiroshi Mukae AU - Kazuhiro Nagata AU - Shigeru Kohno Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P5125.abstract N2 - Heat shock protein (HSP) 47 is involved in the processing and/or secretion of procollagen. The aim of this study was comparative analysis of the diagnostic value for drug induced lung diseases (DILD) of serum levels of HSP47, KL-6, surfactant protein (SP)-A, SP-D, and lactate dehydrogenase (LDH). The findings of high-resolution computed tomographic chest scans of 19 patients with DILD were reviewed separately by two independent observers. The DILD was classified into four predominant patterns: diffuse alveolar damage (DAD) (n = 6), hypersensitivity pneumonitis (HP) (n = 6), nonspecific interstitial pneumonia (NSIP) (n = 6), and organizing pneumonia (OP) (n = 1). The PaO2/fraction of inspired oxygen ratios of the DAD group were significantly lower compared with those of the NSIP and HP groups. The Sequential Organ Failure Assessment (SOFA) score of the DAD group were significantly higher compared with those of the NSIP group. Patients with the DAD pattern had serum HSP47 levels that were significantly higher than those with the NSIP or HP pattern, whereas serum levels of KL-6, SP-A, SP-D, and LDH were not significantly different among the patients groups. Receiver operating characteristic curves revealed that HSP47 was superior to the other markers for discriminating between the DAD group and the other groups. The cut-off level for HSP47 that resulted in the highest diagnostic accuracy was 530.0 pg/ml. The sensitivity, specificity, and diagnostic accuracy were 100.0%, 92.3%, and 94.7%, respectively. The serum HSP47 levels were significantly correlated with respiratory parameters and SOFA score. The present results suggest that serum levels of HSP47 may be a useful marker for DILD. ER -