RT Journal Article
SR Electronic
T1 Recurrence of sarcoid granulomas in lung transplant recipients is common and does not affect overall survival
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2687
VO 42
IS Suppl 57
A1 Hans Henrik Schultz
A1 Claus Andersen
A1 Daniel Steinbrüchel
A1 Michael Perch
A1 Jørn Carlsen
A1 Martin Iversen
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2687.abstract
AB BackgroundSarcoidosis represent 2.5% of all indications for lung transplantation. Recurrence of granuloma has earlier been proved to derive from recipient immune cells, but its role in relation to lung function and overall survival after lung transplantation remains uncertain.ObjectiveTo identify patients with re-occurence of granuloma in transplanted lungs, and compare these patients with other patients transplanted for sarcoidosis without re-occuring granulomas. We compared these patients on survival and lung functionDesignA total of 620 patients were transplanted in Copenhagen from 1992 until august 2012. This study comprised all patients (n=25) transplanted due to end-stage pulmonary sarcoidosis. We reviewed all lung functions and trans-bronchial biopsies and lung functions until today. Granuloma was defined as formation of epitheloid giant cells without presence of infection.ResultsA total of 7 (28%) patients had re-occurence of granuloma and 18 (72%) did not. Recurrent granuloma were persistent in 9/17 biopsies (53%) after first definite finding. There was no difference in best obtained FEV1 (P=0,458), and last FEV1 recorded (P=0,389). There was no difference in survival (Log Rank test P=0,399).ConclusionsApproximately 30% of lung transplant recipients due to endstage sarcoidosis have recurrence of sarcoid granulomas. Recurrence of granulomas does not affect overall survival or lung function.