@article {KodguleP3953, author = {Rahul Kodgule and Nitin Vanjare and Shweta Rasam and Satish Bhosale and Yogesh Gupta and Sundeep Salvi}, title = {Can impulse oscillometry and body plethysmography differentiate response to two salbutamol doses?}, volume = {42}, number = {Suppl 57}, elocation-id = {P3953}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background: Whether sensitive lung function tests like Impulse Oscillometry (IOS) \& Body Plethysmography (BP) can differentiate response between two doses of bronchodilator is not known.Aim: To study the effect of 100 and 400 mcg of salbutamol on IOS \& BP parameters?Methods: In this ongoing study, 9 asthma \& 10 COPD patients were randomized to receive either 100 mcg or 400 mcg of inhaled salbutamol in a cross-over manner. IOS to study resistances at 5 Hz, 20 Hz and 5-20 Hz (R5, R20 and R5-20), BP to study specific airway conductances sGawtot \& sGaweff \& spirometry to study FEV1 \& FEF25-75 was done before and 30 min after drug administration. Within group \& between group changes were analyzed by paired t-test \& independent t-test respectively.Results: The mean percent changes (MPC) for each drug are shown in Table 1.View this table:Table 1: Mean percent change (MPC) in asthmaAll individual responses were statistically significant (p value\<0.5) but 400 mcg of salbutamol did not produce better response than 100 mcg. R5, R20, R5-20 \& FEF25-75\% showed maximum differentiation between two doses.Conclusion: This ongoing study suggests that FEF25-75\%, R5, R20 \& R5-20 may differentiate between response to low \& high doses of bronchodilator.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P3953}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P3953.full.pdf}, journal = {European Respiratory Journal} }