RT Journal Article
SR Electronic
T1 A randomized study of the bronchoscopic valve blockade of the affected part of the lung in the complex treatment of patients with cavitary drug-resistant pulmonary tuberculosis with treatment failure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4460
VO 42
IS Suppl 57
A1 Sergey Sklyuev
A1 Denis Krasnov
A1 Elena Mishkova
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4460.abstract
AB In according to the existing hypothesis application of the endobronchial valve will result in a selective curative atelectasis of the affected part of the lung, which contributes to early closure of cavities.Aims: To assess and to analyze the influence of the endobronchial-valve therapy on the current of the disease.Methods: We have compared the efficacy of endobronchial-valve therapy in the complex treatment of patients with cavitary drug-resistant pulmonary tuberculosis against the standard therapy. The closure of cavities was selected as a criterion of effectiveness. In total, 102 patients with drug-resistant destructive pulmonary tuberculosis were taken into the study, they were randomly divided on two groups - one for 49 patients for endobronchial-valve installation (EBV) and another – for 53 to receive standard treatment (control group). Standard chemotherapy for all groups was administered continued throughout the study period.Results: 33 cases (67,3%) in the EBV-group have demonstrated closure of cavities versus 11 (20.7%) patients in the control group (p < 0.0001). Cavities remained in 16 cases (32.7%) in the EBV-group and in 42 cases (79.3%) of the control group (p < 0.0001).Conclusions: The application of endobronchial-valve treatment can significantly improve the effectiveness of standard chemotherapy regimens for DR cavitary pulmonary.