PT  - JOURNAL ARTICLE
AU  - Swapna Mandal
AU  - Eui-Sik Suh
AU  - Michelle Ramsay
AU  - John Moxham
AU  - Nicholas Hart
TI  - Effect of heated humidification during initiation of home mechanical ventilation (HMV): A randomised cross-over trial
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2469
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2469.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2469.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - INTRODUCTION:Heated humidification(HH) use during HMV is controversial. We hypothesised HH would reduce comfort during HMV initiation due to increased dead space and reduced triggering performance.METHODS:Consecutive patients were enrolled.Patients received NIV with HH(MR810 Fisher Paykel NZ) or without(NH) for 3 weeks, then crossed over.Patients underwent overnight studies after each 3 week period with parasternal electromyogram(EMGpara), respiratory inductance plethysmography, mask pressure, transcutaneous oxygen(SpO2) and carbon dioxide(TcCO2) monitoring.Health related quality of life(HRQL) measures:Severe Respiratory Insufficiency(SRI) questionnaire and comfort with visual analogue scores(VAS).RESULTS:12 patients(5males) have been recruited to date(age 61±10years).Paired data are presented for 9.There was a difference in bicarbonate(mmol/l) between baseline and the end of each treatment period(baseline34±3, NH32±4 and HH31±4; p<0.05).There was no difference in EMGpara and TcCO2 between the groups, however, there was a fall from baseline in the HH group.There was a significant difference between the IPAP and mask pressure during NH arm(p=0.03).There was no difference in overall HRQL and VAS between the groups, however some components in the SRI improved during HH.CONCLUSIONS:These data demonstrate HH does not adversely affect HMV and may enhance ventilation shown by the greater fall in TcCO2.