RT Journal Article SR Electronic T1 Clinical effectiveness of antidepressive drug in patients with COPD and concomitant moderate depressive episode JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3653 VO 42 IS Suppl 57 A1 Yira Feshchenko A1 Ludmila Iashyna A1 Maryna Polianska A1 Inna Zvol A1 Alyona Potocjniak A1 Ludmila Savelieva YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P3653.abstract AB Aim of study: to study the effectiveness of agomelatin on clinical symptoms in COPD patients with moderate depressive episode (DE). Study was carried out because of budjet cost.Materials and methods: 19 COPD (post BD FEV1/FVC<0,7) patients with moderate DE (PHQ-9 score > 15), 7 female and 12 male, mean age (61,7 ± 2,6) years received agomelatin 25 mg 1 hour before sleep OD during 4 weeks on the background of standard COPD therapy according severity. Depressive episode was verified by psychiatrist. Patients were assessed with questionnaires PHQ-9, MADRS, mMRC, CAT score, EQ-5D, also were performed 6-min walk test with BORG scale (physical tolerability) in baseline, in 2 and 4 weeks.Results: Signs of depression significantly (p<0,05) improved after 2 weeks of studied treatment with further positive dynamics on 4 week : PHQ-9 improved from (16,4 ±0,4) to (12,5 ±1,1) after 2 weeks and to (10,4±1,1) to 4 week, MADRS – from (25,0±1,2) to (19,1±1,4) and to (17,3±1,4) accordingly. Positive psychiatry changes were accompanied with improvement of clinical signs of COPD: significantly (p<0,05) decreased at the end of 4 week vs baseline data: dyspnea (mMRC) from (2,4 ±0,2) to (2,1±0,1), CAT test – from (20,9±1,6) to (17,9±1,5), EQ-5D from (9,1 ±1,6) to (7,9±0,5). Physical tolerability improved – walking distance increased from (258,7±11,3) m to (277,4 ±12,2) m (p<0,05).Conclusion: use of agomelatin in complex COPD therapy in patients with COPD and moderate depressive episode caused decrease of depressive signs after 2 weeks of therapy with further improvement to 4 week. Clinical signs of COPD, including tolerability of physical load also improved (p<0,05).