RT Journal Article
SR Electronic
T1 Neutrophil gelatinase-associated lipocalin (NGAL) is associated with a reduced decline in FVC in male COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4222
VO 42
IS Suppl 57
A1 Gunnar R. Husebø
A1 Marianne Aanerud
A1 Thor Ueland
A1 Jon A. Hardie
A1 Per S. Bakke
A1 Tomas M. Eagan
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4222.abstract
AB Background: We have previously shown that the antimicrobial peptide NGAL is a biomarker in COPD. This study aimed to examine whether plasma-levels of NGAL and C-reactive protein (CRP) can be used to predict changes in lung function.Methods: The study included 433 patients with COPD aged 41-76 from the Bergen COPD cohort study. All patients had an FEV1<80% predicted, FEV1/FVC ratio <0.7, and smoking history of more than 10 packyrs. Plasma levels of NGAL and CRP at baseline were measured with enzyme immunoassays. Lung function parameters (FVC and FEV1) were measured at baseline and every 6 months for 3 years. NGAL and CRP as predictive variables of mean change in FVC and FEV1 were examined by linear mixed regression models, adjusted for age, weight, height, smoking and baseline FVC or FEV1.Results: Mean yearly decline in FVC was 69 ml for women and 115 ml for men, and mean yearly decline in FEV1 was 36 ml for women and 61 ml for men. There was a significant interaction between sex and NGAL, and when analyzing women separately, neither NGAL nor CRP were statistically associated with change in FVC or FEV1 in univariate or adjusted models.However, in men an increase of baseline NGAL (by 10 ng/ml) was associated with a reduced decline of FVC by 9.3 ml/year univariately (p=0.01), with almost identical findings in the adjusted model: 9.7 ml/year (p=0.01). In contrast, increased baseline CRP predicted a larger decline in FVC, by 2.7 ml/year (per 1 μg/ml CRP, p=0.04) in the adjusted model. Neither NGAL nor CRP were associated with change in FEV1 univariately nor adjusted.Conclusion: In men, NGAL and CRP levels at baseline were related to yearly change of FVC, but not FEV1.