@article {TeopompiP2112, author = {Elisabetta Teopompi and Giovanna Pisi and Marina Aiello and Roberta Pisi and Paolo Mangano and Francesco Longo and Patrizia Riz{\`e} and Candida Tripodi and Valentina Fainardi and Enrico Clini and Alfredo Chetta and Angelo Sala}, title = {Is the unbalance between arachidonic acid and docosahexaenoic acid a reversible condition in adults With cystic fibrosis?}, volume = {42}, number = {Suppl 57}, elocation-id = {P2112}, year = {2013}, publisher = {European Respiratory Society}, abstract = {In patients with cystic fibrosis (CF), a significant reduction in docosahexaenoic acid (DHA), a fat acid involved in inflammatory changes, may occur. We assessed the arachidonic acid (AA) and DHA metabolites in sputum of 15 CF patients, as compared to 10 COPD patients, and their changes after ten weeks of DHA supplementation. At baseline all subjects were assessed by nutritional status, spirometry, sputum sample to measure leukotriene B4 (LTB4), prostaglandin E2 (PGE2), 15-hydroxyeicosatetraenoic acid (15-HETE), 17-hydroxydocosahexaenoic acid (17OH-DHA), 15-HETE/17OH-DHA ratio, and blood sample to measure DHA/AA ratio and HUFA index. CF patients repeated assessments ten weeks after DHA-supplementation and after ten weeks without. As compared to COPD patients, CF subjects showed increased concentrations of LTB4 (p \< 0.0001), PGE2 (p \< 0.0001), 15-HETE (p \< 0.0001), while the concentrations of the 17OH-DHA was not different in the two groups. Following DHA supplementation, CF subjects had a tendency to decrease in LTB4 and PGE2 and to increase in 17OH-DHA concentrations, and a significant reduction in 15-HETE (p = 0.0137). At the end of the washout period, LTB4, PGE2, 15-HETE, and 17OH-DHA recovered toward baseline values. In blood samples after DHA supplementation, DHA/AA ratio and HUFA index significantly increased (p = 0.05), while 15-HETE/17OH-DHA ratio significantly decreased (p = 0.01) compared to baseline. Our preliminary results have shown that in CF patients an impairment in fatty acid metabolism, characterized by increase in AA metabolites and decrease in DHA, may occur as compared to COPD patients and was partially corrected by DHA supplementation.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P2112}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P2112.full.pdf}, journal = {European Respiratory Journal} }