RT Journal Article
SR Electronic
T1 Prospective audit examing the resting energy expenditure (REE) of paediatric patients with CF
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3613
VO 42
IS Suppl 57
A1 Marianne O Reilly
A1 Clodagh Dempsey
A1 Denise Moran
A1 Mary Morgan
A1 Dubhfeasa Slattery
A1 Fiona Healy
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3613.abstract
AB REE represents the calories required over a 24-hour period by the body during an inactive period. REE is 10-20% greater in CF patients than in healthy controls (Vaisman N et al. J pediatr, 1987, 111, 496-500: Buchdahl RM et al. J App Phys, 1988, 64, 1810-16). The reasons for this are poorly understood. The objective of this study was to evaluate factors that may influence REE in CF. REE was measured with indirect calorimetry in 35 patients (females = 12) at respiratory baseline (9.5yrs-15.2yrs) during routine review. Other parameters collected at this time point included lung function (FEV1), weight, height, genotype and PEG. Mean REE was 107% predicted. The increase was greater in females (110%) than males (102%). There was no significant difference in REE in the pubertal group. A small positive association was found between age and REE. There was a small positive correlation between FEV1 and REE. Increased weight was associated with higher REE. There was no association between height and REE. Those homozygous for Delta f508 (17/35) had lower % REE than those with other genotypes (105 v 121) but these results were not statistically significant. Those with PEG tubes (12/35) had lower REE than those without (105 V 115) and also had a lower FEV1 (60% V 91%). Overall, while REE was elevated it was lower than seen in other studies. The higher REE seen in females is well documented in other studies. The higher REE seen in those with better FEV1 and non homozygous delta f508 genotypes should in future be interpreted alongside body composition and physical activity levels. It is possible that those with PEG have lower REE due to reduced physical effort as a result of decreased lung function.