PT - JOURNAL ARTICLE AU - Leila Donária AU - Rafael Mesquita AU - Mônica Yosino AU - Larissa Martinez AU - Josiane Marques Felcar AU - Nidia A. Hernandes AU - Vanessa S. Probst AU - Fabio Pitta TI - Relationship between sniff nasal inspiratory pressure and the multidimensional BODE index in patients with COPD DP - 2013 Sep 01 TA - European Respiratory Journal PG - P3172 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P3172.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P3172.full SO - Eur Respir J2013 Sep 01; 42 AB - Introduction: Inspiratory muscle force has been traditionally assessed by maximal inspiratory pressure (MIP). The sniff nasal inspiratory pressure (SNIP) is an alternative to the MIP and is considered as predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). However, the relationship of SNIP with multidimensional indexes which predict mortality in COPD patients such as the Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (BODE) has not yet been investigated. Objective: To investigate the relationship between SNIP and BODE index in COPD patients COPD. Methods: Thirty-eight subjects with COPD (21 men, 66±8 years, FEV1 42±16% of predicted) underwent assessments: SNIP, spirometry, degree of dyspnea (Medical Research Council scale) and 6-minute walk test. The BODE index was calculated and the patients were divided into four quartiles according to the BODE score. Results: There was significant difference in the SNIP (cmH2O and %predicted) when patients in the different BODE quartiles were compared. The SNIP (cmH2O and %predicted) showed moderate correlation with the BODE and the updated BODE (-0.45<r<-0.62). A logistic regression analysis was used to determine the association of the BODE between three differents cutoffs of SNIP previously used in the literature, and there was statistical significance only for the cutoff 63 cmH2O (OR: 4.67, 95% CI 1.19 to 18.35, P= 0.03). Conclusion: SNIP is moderately and significantly related with the BODE index in COPD patients. Moreover, the cutoff point of 63 cmH2O showed the best combination of sensitivity and specificity for predicting a higher (i.e., worse) score in the BODE index.