TY - JOUR T1 - Serum leptin and adiponectin in obese and non-obese asthmatic school children: Relation to asthma control JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P1125 AU - Atqah Abdul Wahab AU - Muna Maarafiya AU - Ashraf Soliman AU - Noura Younes AU - Prem Chandra Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P1125.abstract N2 - Background:There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin are produced by adipose tissue that regulates several metabolic and inflammatory functions.Purpose: To measure serum leptin and adiponectin concentrations in obese asthmatic (OA) and non-obese asthmatic (NOA) children, and to investigate the association between their levels in relation to asthma control.Methods: OA and NOA children, aged 7 to 14 years were enrolled in the study. The subjects were distributed into three groups according to their asthma control levels (well controlled, partial controlled and uncontrolled asthma). Body mass index (BMI) Z score, spirometry, IgE, serum leptin and adiponectin were measured.Results: Serum leptin levels in 29 OA were significantly higher compared to 31 NOA children (25.8±11.1vs 8.7±11.1: (P<0. 001) and serum adiponectin in OA was significantly lower compared to NOA children (2.5±1.2.vs 5.42 ±2.93: (P<0. 001). Although not statistically significant, the uncontrolled group has serum leptin levels higher and serum adiponectin levels lower compared to well controlled and partial controlled asthma. Serum leptin levels demonstrated positive correlation and adiponectin demonstrated negative correlation with BMI. BMI Z score did not differ significantly among the asthma control groups.Conclusion: BMI Z score, leptin and adiponectin concentrations did not differ significantly among the asthma severity groups ruling out a significant effect of these variables on the severity of asthma control. A larger prospective study needs to be conducted for generalization and validity of the above findings. ER -