@article {Rother5047, author = {Catriona Rother and Waleed Salih and Aran Singanayagam and James D. Chalmers}, title = {Low frequency of resistant pathogens in nursing home acquired pneumonia: A prospective study and systematic review}, volume = {42}, number = {Suppl 57}, elocation-id = {5047}, year = {2013}, publisher = {European Respiratory Society}, abstract = {IntroductionIt has been suggested that nursing home acquired pneumonia (NHAP) should be managed differently to community-acquired pneumonia (CAP) due to a higher frequency of potentially resistant pathogens.MethodsThis study describes two analyses: first, a prospective observational study of 1883 patients with CAP was used to compare microbiology between NHAP and CAP patients. Patients were classified as NHAP or CAP based on admission residency status. In the second analysis, a systematic review and meta-analysis compared the microbiology and outcomes of NHAP compared to CAP from all published comparative studies. Methicillin resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and enterobactericeae were studied as potentially resistant organisms.ResultsIn the prospective study, there were 171 nursing home residents. S. pneumoniae was the most frequent causative organsim in both groups. There was no increased frequency of MRSA (0.6\% in NHAP vs 0.4\% in CAP,p=0.6), P. aeruginosa (0.6\% vs 0.5\%,p=0.8) or enterobactericeae (2.3\% vs 1.2\%,p=0.2) in NHAP compared to CAP.In the systematic review and meta-analysis, 6 studies were identified including 6444 patients. There was no significant increase in the frequency of MRSA (OR 0.28 95\% CI 0.03-2.76,p=0.3) or P. aeruginosa (0.63 95\% CI 0.31-1.30,p=0.2) but a statistically significant increase in enterobactericeae (1.41 95\% CI 1.01-1.97,p=0.04) was identified. Patients with NHAP were more likely to die (3.25 95\% CI 2.06-5.15,p\<0.0001) but were not more likely to require ICU admission (0.48 95\% CI 0.13-1.74,p=0.3).ConclusionOur findings do not support a change in antibiotic prescribing practices for NHAP patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/5047}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/5047.full.pdf}, journal = {European Respiratory Journal} }