@article {OmlandP3082, author = {{\O}yvind Omland and Tine Malling and Jens Peter Johansen and Johnni Hansen}, title = {Exposure assessment and co-morbidity in females with malignant mesothelioma referred to an occupational clinic}, volume = {42}, number = {Suppl 57}, elocation-id = {P3082}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Aim. To describe asbestos exposure and to identify co-cancer morbidity in 14 consecutive female patients (1987 -2012) with malignant mesothelioma (MM).Method. From medical records we identified age, asbestos exposure, localisation and subtypes of MM, and other cancer forms involving only pathological verified diagnosis.Results. Median age was 62 years (min 43 - max 81). We identified in 2 cases (14\%) both occupational and domestic exposure, in 4 (29\%) occupational exposure, in 4 (29\%) domestic exposure, while in 4 cases (29\%) no asbestos exposure was identified. Domestic exposure was cleaning husband or sons working clothes. 9 cases of MM (71\%) were localized to pleura and 5 (29\%) to peritoneum. 7 (59\%) of the cases were epitheloid subtype, and 2 (14\%) were biphasic. 5 cases (36\%) missed subtype description. In 6 cases (43\%) of MM other cancer forms were diagnosed prior to MM diagnose; in 3 localized to peura 2 cases of breast cancer and 1 case of colon cancer were diagnosed and in 3 localized to peritoneum 1 case of lung cancer, 1 case of breast cancer and in 1 case both cervix cancer and lung cancer were diagnosed. A non significant reduced survival time (423 days vs. 1068 days) was observed for cases with MM and another cancer compared to cases with MM alone.Conclusion: Occupational and domestic asbestos exposure was an equal contributor to MM and in 29\% of the cases no asbestos exposure was identified. The prevalence of cancers diagnosed prior to MM in the patients exceeds the Danish life prevalence of breast- (10\%), colon- (5.5\%), cervix (1.5\%), and lungcancer (4\%). Reduced immune system surveillance and radiation- and chemotherapy might be involved.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P3082}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P3082.full.pdf}, journal = {European Respiratory Journal} }