TY - JOUR T1 - Short term outcome of isolated tuberculous lymphadenitis (TBL); a series of 152 cases JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2802 AU - Dushantha Madegedara AU - Manjula Weerakoon AU - Duminda Yasaratne AU - Damith Nandadeva AU - Hansa Kumara Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2802.abstract N2 - Aim To assess the short-term outcome of TBL, in an endemic setting with intermediate disease burden.Setting Respiratory Unit II, Kandy, Sri Lanka.Methodology A descriptive case series from TB registry, Jan 2008 - Dec 2011.Results Out of total 3410 TB patients, 933 (27%) were extrapulmonary. 152 (86 females; mean age 36.0 years) had isolated lymphadenitis. Cervical nodes were the commonest involved in 79%. 144 had histological and/or microbiological confirmation, while 8 were treated on strong clinical grounds.49 (34%) of confirmed cases did not respond to initial six month course of category I anti-tuberculous treatment (ATT), but all responded to prolonged or alternative therapy. Some of them required category II ATT, while repeat LN biopsy showed coexisting fungal & atypical mycobacterial disease in a few. Five with large residual nodes had them surgically excised. Among the empirically treated cases, alternative or coexisting diagnoses including malignancy and lymphoma, were made in 5 (62%) on early reassessment.All were HIV negative and drug resistance not identified in the group. Only 9 developed major adverse reactions (hepatitis 8, vestibular neuronitis 1) to ATT.Conclusion TBL showed a varying response to a six month course of category I ATT. One third of confirmed cases warranted treatment modifications for good response in our setting. Majority of empirically treated cases had alternative diagnoses. ER -