RT Journal Article
SR Electronic
T1 Study assoicção between severity stages of chronic obstructive pulmonary disease and fasting glucose in patients with this disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2085
VO 42
IS Suppl 57
A1 Marianna Ribeiro
A1 Guilhardo Ribeiro
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2085.abstract
AB COPD is a respiratory disease that is characterized by the presence of chronic airflow obstruction. The pathophysiological process of this disease involves the release of proinflammatory cytokines due to chronic inflammation, leading to a systemic effect from these cytokines released. Among the effects, cytokines act by altering the metabolism of glucose and changing the insulin resistance in patients with COPD. Objective: Join the severity stages of Chronic Obstructive Pulmonary Disease and fasting plasma glucose in patients with this disease. Study design: an observational study, cross-sectional, with data collection for 24 months. Methods: We evaluated 70 patients in the Outpatient COPD, the HSI. To confirm the diagnosis of COPD were performed in all patients with a clinical assessment and spirometry test with pharmaco-dynamics. After confirming the diagnosis of COPD, fasting glucose was requested. After confirming the diagnosis of COPD was requested fasting for the association between them. Results: Patients with COPD grade I showed 64.3% of normal glycemia, 14.3% of insulin resistance and diabetes mellitus of 21.4%. COPD patients showed grade II 61.1%% of normal glycemia, 11.1%% of insulin resistance and 27.8%% of diabetes mellitus. Patients with COPD stage III showed 68.0%% of normal glycemia, 16.0%% of insulin resistance and 16.0%% of diabetes mellitus. COPD patients showed 38.5% grade IV% of normal glycemia, 30.8%% of insulin resistance and 30.8%% of diabetes mellitus. Conclusion: The results of this study showed that there is a positive association between stages of COPD severity and glycemic alterations in these patients.