%0 Journal Article %A Dnyaneshwar Taur %A Raju Patil %A Ravindra Patil %T Bioactivity-guided isolation of bronchodilator fraction from clitoria ternatea roots %D 2013 %J European Respiratory Journal %P P740 %V 42 %N Suppl 57 %X Introduction: Asthma is regarded as a lifetime disorder of airway and which require long term multitargated therapy for its management.Aim and Objectives: To overcome these adverse effects of synthetic drugs there is much interest in plant derived medicine for the management asthma have been increased. The roots of Clitoria ternatea Linn family Fabeaceae have been traditionally used for the treatment of asthma.Method: In present study seven fractions F3 to F8 and F10 isolated from ethanol extract of C. ternatea (50 mg/kg) were tested on histamine induced bronchospam in guinea pig using salbutamol (2 mg/kg) as standard drug (Patel, K.G. et al. Iranian Biomedical J 2008; 12(3): 191-196). The time required for onset of preconvulsive dyspnoea was recorded. Among these most significant fraction was rechromatographed and phytoconstituent was identified by spectroscopic method.Results: Result of study reveals that fraction F7 significantly protects guinea pig against histamine induced bronchoconstriction as shown in Figure 1.Compound separated from fraction F7 was identified as taraxerol.Conclusions: In conclusion C. ternatea may be used in the treatment of asthma it may be due to presence of taraxerol. %U https://erj.ersjournals.com/content/erj/42/Suppl_57/P740.full.pdf