RT Journal Article
SR Electronic
T1 Associations with a change in tracking of lung function
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1619
VO 42
IS Suppl 57
A1 Steve Turner
A1 David Mullane
A1 Des Cox
A1 Jack Goldblatt
A1 Louis Landau
A1 Peter Le Souef
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P1619.abstract
AB BackgroundRecent work has demonstrated tracking of lung function from early infancy to ages 18 and 22 years. We hypothesised that factors associated with wheeze would be associated with a changing trajectory of lung function tracking during infancy and childhood.MethodsLung function was measured longitudinally at one, six and twelve months (V’maxFRC) of age and at ages six, twelve and eighteen years (FEF25-75). Repeated measures analysis of variance was used to explore chronological changes in % lung function. Results were analysed using the 91 individuals with data at all ages apart from 6 years (“restricted analysis”) and then for all individuals after replacing missing values with average values for that age (“whole cohort analysis”).ResultsThe % lung function was determined in 241 individuals aged one month, 192 six months, 164 twelve months, 106 six years, 183 twelve years and 141 eighteen years. In the restricted analysis, maternal asthma was associated with reduced lung function from twelve months to 18 years (p=0.006). In the whole cohort analysis, associations were observed between: infant onset atopy and reduced lung function from six to 18 years (p=0.005); flow limitation at one month and reduced lung function only up to age six years (p<0.001); and maternal asthma and reduced lung function only at age 18 years (p=0.016).ConclusionsThe repeated measurements of lung function in our cohort have allowed identification of factors associated with changes in lung function growth. These include early lung function, early onset atopy and maternal asthma and one or other may be associated with acceleration in infants with low initial lung function or deceleration in those with normal initial lung function.